The Toffees will hope to bounce back from their humbling defeat to Tottenham last weekend and the former Southampton manager has said he is taking the Europa League very seriously.
James McCarthy, Ross Barkley, Ramiro Funes Mori, Yannick Bolasie and Seamus Coleman are all currently on the treatment table, while winger Aaron Lennon has not travelled to Italy.
Atalanta were one of last season’s surprise packages in Serie A but tonight’s game will be played 120 miles from their home – at Sassuolo’s Mapei Stadium – because their Stadio Atleti Azzurri d’Itali ground is being renovated.
So who will start tonight’s Europa League tie? The confirmed teams are available in full below.
Atalanta XI: Berisha, Toloi, Palomino, Masiello, Hateboer, Cristante, Freuler, de Roon, Castagne, Petagna, Gomez
Substitutes: Gollini, Orsolini, Cornelius, Caldara, Kurtic, Haas, Bastoni
Everton XI: Stekelenburg, Holgate, Jagielka, Keane, Baines, Besic, Schneiderlin, Rooney, Vlasic, Sigurdsson, Calvert-Lewin
Substitutes: Pickford, Williams, Sandro, Mirallas, Martina, Gueye, Klaassen